The best Side of (S)-Afatinib
Desk 1 summarizes the noticed DLTs by cohort. Somnolence, which settled in all but 1 patient, was the one DLT for MLN8054 provided with out methylphenidate or modafinil. The onset of somnolence and its severity usually have been correlated with dose and Cmax. Since somnolence was considered connected with Cmax, the dosing plan was modified from eac